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Metabolomics analysis is the study of small molecules and metabolites within cells, tissues, biofluids, and organisms. By measuring changes in metabolite concentrations, researchers gain insights into biological pathways, disease mechanisms, environmental influences, drug responses, and physiological processes.

Metabolomics Analysis for Biomarker Discovery and Metabolite Profiling

Uncover What’s Beneath the Surface of Your Metabolomics Data

For years, scientists have turned to LECO to deliver the sensitivity and accuracy needed to go beyond the surface of metabolomics. Whether deciphering the intricate metabolic pathways of a disease or exploring new horizons in exposomics, our advanced instruments, streamlined workflows, and innovative software tools are designed to solve the toughest analytical challenges.

Scroll through our application notes, webinars, and featured instruments, to discover how LECO empowers researchers to transform data into groundbreaking insights. Move from research to discovery, faster and more confidently than ever

Webinars

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Application Notes

Comprehensive GC-TOFMS Metabolomics Workflow

A Comprehensive GC-TOFMS Metabolomics Workflow

This workflow uses automated derivatization of plasma, GC-TOFMS analysis, and ChromaTOF Sync data processing to detect metabolite biomarkers for early type-2 diabetes diagnosis.
Genetic metabolite research

Utilizing GCxGC for improved yeast metabolite characterization

This application note demonstrates the use of GC-HRT and GCxGC-HRT for comprehensive metabolomic profiling of yeast. By combining enhanced chromatographic resolution with high-resolution, accurate-mass detection, researchers can better characterize complex metabolic pathways, supporting advances in systems biology and bioengineering applications such as bioethanol and sustainable chemical production.
Corn and yeast metabolite characterization

Metabolomic Profiling Rice and Corn with GC-TOFMS

This study demonstrates the use of LECO’s Pegasus BT GC-TOFMS for metabolomic profiling of corn and rice. Optimized for speed and broad metabolite detection, the system enables comprehensive analysis of biochemical traits that influence crop quality, yield, nutritional content, and stress tolerance. Powerful software tools support peak finding, annotation, and rapid data interpretation for enhanced…
blood cell profiling

Using GC-HRT TOFMS to detect PCBs in liver tissues

Liver disease affects more than 800 million people worldwide causing at least 1.5 million deaths annually. Mice provided a reliable model for detection of polychlorinated biphenyls (PCBs) associated with non-alcoholic fatty liver disease.
model of human blood cells

Enhanced Metabolite Profiling with High Resolution TOFMS

Explore electron impact and chemical ionization in high-resolution time-of-flight mass spectrometry for enhanced metabolite profiling.
Blue cell simulation of metabolomic analyses

Comprehensive Molecular Profiling using HR-TOFMS

This study demonstrates the use of LECO’s Pegasus GC-HRT for urine analysis, enabling high-resolution molecular profiling and monitoring of drug use. With rapid acquisition, high mass accuracy (<1 ppm), and resolving power up to 50k, the instrument provides high-quality spectral data for confident compound identification through library searching, molecular formula determination, and evaluation of metabolites and…
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The LECO Difference

Trusted expertise, groundbreaking technology, and a commitment to your success.

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Uncover Hidden Insights

Time-of-Flight mass spec delivers unparalleled non-target data, every chemical feature captured.

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Maximize Annotation Accuracy

High resolution, accurate mass instruments paired with ionization source flexibility provide analysts every clue to annotate with confidence.

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Discovery, Simplified

End-to-end software solutions can rapidly identify potential biomarkers, monitor metabolism behavior over time, and much more.

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Best in Class Service

We dedicate ourselves to your success through unmatched support, training, and fast service.

Instruments & Software

Pegasus BTX Series

High-sensitivity Time-of-Flight Mass Spectrometer

Pegasus HRT Series

High resolution GC and GCxGC-TOF-MS

ChromaTOF Sync

Data Alignment and Comparison Software

ChromaTOF Tile

Visually compare GCxGC datasets

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