Metabolomics Analysis for Biomarker Discovery and Metabolite Profiling
Uncover What’s Beneath the Surface of Your Metabolomics Data
For years, scientists have turned to LECO to deliver the sensitivity and accuracy needed to go beyond the surface of metabolomics. Whether deciphering the intricate metabolic pathways of a disease or exploring new horizons in exposomics, our advanced instruments, streamlined workflows, and innovative software tools are designed to solve the toughest analytical challenges.
Scroll through our application notes, webinars, and featured instruments, to discover how LECO empowers researchers to transform data into groundbreaking insights. Move from research to discovery, faster and more confidently than ever before.
Webinars
Application Notes
A Comprehensive GC-TOFMS Metabolomics Workflow
A Comprehensive GC-TOFMS Metabolomics Workflow
This workflow uses automated derivatization of plasma, GC-TOFMS analysis, and ChromaTOF Sync data processing to detect metabolite biomarkers for early type-2 diabetes diagnosis.
Utilizing GCxGC for improved yeast metabolite characterization
Utilizing GCxGC for improved yeast metabolite characterization
This application note demonstrates the use of GC-HRT and GCxGC-HRT for comprehensive metabolomic profiling of yeast. By combining enhanced chromatographic resolution with high-resolution, accurate-mass detection, researchers can better characterize complex metabolic pathways, supporting advances in systems biology and bioengineering applications such as bioethanol and sustainable chemical production.
Metabolomic Profiling Rice and Corn with GC-TOFMS
Metabolomic Profiling Rice and Corn with GC-TOFMS
This study demonstrates the use of LECO’s Pegasus BT GC-TOFMS for metabolomic profiling of corn and rice. Optimized for speed and broad metabolite detection, the system enables comprehensive analysis of biochemical traits that influence crop quality, yield, nutritional content, and stress tolerance. Powerful software tools support peak finding, annotation, and rapid data interpretation for enhanced…
Using GC-HRT TOFMS to detect PCBs in liver tissues
Using GC-HRT TOFMS to detect PCBs in liver tissues
Liver disease affects more than 800 million people worldwide causing at least 1.5 million deaths annually. Mice provided a reliable model for detection of polychlorinated biphenyls (PCBs) associated with non-alcoholic fatty liver disease.
Enhanced Metabolite Profiling with High Resolution TOFMS
Enhanced Metabolite Profiling with High Resolution TOFMS
Explore electron impact and chemical ionization in high-resolution time-of-flight mass spectrometry for enhanced metabolite profiling.
Comprehensive Molecular Profiling using HR-TOFMS
Comprehensive Molecular Profiling using HR-TOFMS
This study demonstrates the use of LECO’s Pegasus GC-HRT for urine analysis, enabling high-resolution molecular profiling and monitoring of drug use. With rapid acquisition, high mass accuracy (<1 ppm), and resolving power up to 50k, the instrument provides high-quality spectral data for confident compound identification through library searching, molecular formula determination, and evaluation of metabolites and…
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