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Unlock the Truth in Every Peak

ChromaTOF

Software for GC-TOFMS and GCxGC

ChromaTOF Software is the powerful data processing engine behind LECO’s GC, GCxGC, and TOFMS platforms. Designed for researchers who demand accuracy, speed, and confident results, ChromaTOF transforms complex chromatographic and mass spectral data into actionable insights. With advanced deconvolution, streamlined workflows, and intuitive visualization tools, it enables users to maximize instrument performance and accelerate discovery across environmental, petrochemical, metabolomics, flavor and fragrance, forensics, and life‑science applications.

The Standard in Automated Peak Identification

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Industry-Leading Deconvolution

Automatically resolve co‑eluting peaks and extract clean mass spectra, ensuring accurate identification even in complex matrices.

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Seamless GCxGC Processing

Native GCxGC support delivers robust contour plots, modulation analytics, and advanced peak tracking tools for confident interpretation.

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Intelligent Workflows

Automated processing templates, batch tools, and reporting options reduce manual workload and improve consistency across labs.

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Built for High-Throughput Analysis

Optimized algorithms handle large data sets from high‑speed TOFMS instruments without compromising speed or accuracy.

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Integrates with Tile & Sync

Works natively with ChromaTOF Tile (statistical discovery tools) and ChromaTOF Sync (collaboration + cloud data access) for a complete data ecosystem.

ChromaTOF Features

Peak Deconvolution
Clean, accurate spectra from complex samples
GCxGC Processing
Native tools for advanced 2D workflows
Retention Index Alignment
More accurate, reproducible IDs
Real‑Time Handling
High‑speed performance for TOFMS data

ChromaTOF Application Notes

Rubber duck on a bat towel next with sponge and soap

Investigation of Musty Malodor in Consumer Bath Towels with GCxGC and TOFMS

The Pegasus BTX TOFMS utilizes comprehensive two-dimensional gas chromatography to resolve complex chemical profiles and identify low-level malodors in used fabrics. This non-targeted workflow allows researchers to pinpoint specific volatile organic compounds that resist standard laundry cycles.

PFAS and Environmental Pollutants in Household Dust

The goal of this work was to develop a methodology for the untargeted analysis of a dust standard reference material (NIST 2585) as well as dust samples collected from household and office settings for both legacy and emerging pollutants. The method uses two-dimensional gas chromatography (GCxGC) and high-resolution mass spectrometry (HRTOFMS), is comprehensive, and covers…

A Comprehensive GC-TOFMS Metabolomics Workflow

This workflow uses automated derivatization of plasma, GC-TOFMS analysis, and ChromaTOF Sync data processing to detect metabolite biomarkers for early type-2 diabetes diagnosis.
Broccoli

Discovery of Sulfur-Containing Compounds in Broccoli with GC-TOFMS

Blue bowl of celery with leaves and stalks

Characterization of Volatile Compounds in Celery Scent

Headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-time-of-flight mass spectrometry (GC-TOFMS) offers a powerful approach for identifying the complex volatile profile of produce. By utilizing mathematical deconvolution and retention index tools, this method successfully resolves coeluting analytes to provide high-confidence characterization of the hundreds of compounds that contribute to the unique aroma of celery.
Explore Additional Applications
The Pegasus 4D enabled me to separate an unbelievable number of analytes—tens of thousands of peaks in one run! Where separation wasn’t perfect, ChromaTOF’s deconvolution algorithm did the job, helping me discover new types of metabolites.
Ph.D. Jan Rezek, Ing., Czech Academy of Science, Tschechische Republik
I use a LECO mass spectrometer for plant metabolomics; it is an efficient machine with a very low detection limit and the ChromaTOF deconvolution algorithm allows to find hundreds of compounds in complex extracts.
Raphaël Lugan, Enseignant Chercheur, UMR QualiSud, University of Avignon, France

Frequently Asked Questions

ChromaTOF is the native software supporting all LECO Pegasus GC and GCxGC-MS platforms, including Pegasus BTX 4D, Pegasus GC-HRT 4D, and earlier models.

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Yes, all tables and plots can be exported for reporting, publication, or further statistical analysis. 

Yes! To help you get up and running quickly, customers can access step-by-step on-demand video tutorials covering the key features and common tasks with LECOLearn.

ChromaTOF is available as a 90-day trial, annual subscription, or as a perpetual USB license.

Visit LECOsoftware.com to download the most up-to-date versions of all LECO software.

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